Ethylenediamine → N-(2-Dimethylaminoethyl)-N'-[2-(2-benzimidazolylmethylamino)-ethyl]thiourea

HRID 1605483

Reaktionsgleichung

[CH2:1]([NH2:4])[CH2:2][NH2:3].Cl[CH2:6][C:7]1[NH:8][C:9]2[CH:15]=[CH:14][CH:13]=[CH:12][C:10]=2[N:11]=1.[CH3:16][N:17]([CH3:23])[CH2:18][CH2:19][N:20]=[C:21]=[S:22]>>[CH3:16][N:17]([CH3:23])[CH2:18][CH2:19][NH:20][C:21]([NH:3][CH2:2][CH2:1][NH:4][CH2:6][C:7]1[NH:8][C:9]2[CH:15]=[CH:14][CH:13]=[CH:12][C:10]=2[N:11]=1)=[S:22]

Komponenten

Edukt 3

HCID 3301Ethylenediamine

HCID 785712-Chloromethylbenzimidazole

HCID 3853726(2-Isothiocyanatoethyl)dimethylamine

Produkt 1

HCID 54373380N-(2-Dimethylaminoethyl)-N'-[2-(2-benzimidazolylmethylamino)-ethyl]thiourea

Versuchsvorschrift

N-(2-Benzimidiazolylmethyl)ethylenediamine, prepared by reacting ethylenediamine with 2-chloromethyl-benzimidazole by the procedure of Example 40, is reacted with 2-dimethylaminoethyl isothiocyanate by the procedure of Example 40 to give the title compound.

Quellen und Nachweise

ORD-Eintrag: ord-26dc98511a5f49779474b95a0cb264db
Quelldatensatz: uspto-grants-1976_04
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US03950353

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