1,3-Dioxolane-2-methanamine, N-methyl- → N-(2-trifluoromethyl-1,3,4-thiadiazol-5-yl)-N'-(1,3-dioxolan-2-ylmethyl)-N'-methylurea
Reaktionsgleichung
[F:1][C:2]([F:12])([F:11])[C:3]1[S:4][C:5]([N:8]=[C:9]=[O:10])=[N:6][N:7]=1.[O:13]1[CH2:17][CH2:16][O:15][CH:14]1[CH2:18][NH:19][CH3:20]>C1C=CC=CC=1>[F:12][C:2]([F:11])([F:1])[C:3]1[S:4][C:5]([NH:8][C:9]([N:19]([CH2:18][CH:14]2[O:15][CH2:16][CH2:17][O:13]2)[CH3:20])=[O:10])=[N:6][N:7]=1Komponenten
4
Versuchsvorschrift
2-Trifluoromethyl-1,3,4-thiadiazol-5-yl isocyanate dimer (3.1 grams) was added to a solution of N-(1,3-dioxolan-2-ylmethyl)-N-methylamine (2grams) in benzene (10 ml) contained in a glass reaction vessel equipped with a mechanical stirrer and thermometer. The mixture was heated on a steam bath for a period of about 1 hour. The mixture was then stripped of solvent under reduced pressure to yield a solid residue. The residue was recrystallized from an ether-pentane mixture to yield the desired product N-(2-trifluoromethyl-1,3,4-thiadiazol-5-yl)-N'-(1,3-dioxolan-2-ylmethyl)-N'-methylurea having a melting point of 114° to 115°C.