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(3-Carboxypropyl)(triphenyl)phosphanium bromide → HCID 86733260, Verbindung

HRID 1606219
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Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 1606219
[Br-].C(CCC[P+](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)(O)=O.[Br-].[C:28]([CH2:31][CH:32]([CH3:56])[CH:33]([CH3:55])[CH2:34][CH2:35][P+](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)([OH:30])=[O:29].[CH2:57]([O:59][C:60]1([CH2:68][CH2:69]CC=O)[CH:64]=[CH:63][CH:62]([O:65][CH2:66][CH3:67])[O:61]1)[CH3:58].C(OC1(CC=O)C=CC(OCC)O1)C>C(O)C>[CH2:57]([O:59][C:60]1(/[CH:68]=[CH:69]\[CH2:35][CH2:34][CH:33]([CH3:55])[CH:32]([CH3:56])[CH2:31][C:28]([OH:30])=[O:29])[CH:64]=[CH:63][CH:62]([O:65][CH2:66][CH3:67])[O:61]1)[CH3:58]
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Komponenten

6

Edukt 4

HCID 10717451(3-Carboxypropyl)(triphenyl)phosphanium bromideHCID 214374262,5-Dihydro-2,5-diethoxy-2-(2'-oxoethyl)furanHCID 214374312,5-Dihydro-2,5-diethoxy-2-(4'-oxobutyl)furanHCID 86733261HCID 86733261, Verbindung

Produkt 1

HCID 86733260HCID 86733260, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

Adaption of the above-described procedures to the preparation of the other compounds of this invention essentially involves the lengthening or shortening of, or the introduction of one or two lower alkyl groups into, the side-chains in furans (I) or (XVII) or in phosphonium derivative (III). These adaptations can be accomplished by procedures well-known to the art. For example, isopropyl γ-(2-furyl)butyrate provides 2,5-dihydro-2,5-di-n-propoxy-2-(3'-carbo-isopropoxypropyl)furan in n-propanol whereas methyl δ-(2-furyl)valerate provides 2,5-dihydro-2,5-diethoxy-2-(4'-carbomethoxybutyl)furan in ethanol when treated in the manner described for the conversion of (I) to (II). Similarly, ω-(2-furyl)caproic acid and ω-(2-furyl)enanthic acid provide 2,5-dihydro-2,5-diethoxy-2-(5'-carboxyentyl)furan and 2,5-dihydro-2,5-diethoxy-2-(6'-carboxyhexyl)furan when treated in ethanol in the manner described for the conversion of (XVII) to (XVIII). Optionally, the furyl acids may be first esterified prior to oxidative alkoxylation, and all 2,5-dihydro-2,5-dialkoxy-2-(carboalkoxyalkyl)furans may be converted to the corresponding aldehydes in the manner described for the conversion of (II) to (IV). Also, the reaction of 3-carboxypropyltriphenylphosphonium bromide and 5-carboxy-3,4-dimethylamyltriphenylphosphonium bromide with 2,5-dihydro-2,5-diethoxy-2-(4'-oxobutyl)furan and 2,5-dihydro-2,5-diethoxy-2-(2'-oxoethyl)furan, respectively, provides the 2,5-dihydro-2,5-diethoxy-2-(7'-carboxy-4'-cis-heptenyl)furan and 2,5-dihydro-2,5-diethoxy-2-(7'-carboxy-5',6'-dimethyl-2-cis-heptenyl)furan.

Quellen und Nachweise

ORD-Eintrag
ord-b9d854bff240412fbd9dc301f30e9cc5
Quelldatensatz
uspto-grants-1976_04
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US03952033

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