HCID 86733267, Verbindung → N-Acetyl-DL-phenylglycine

HRID 1606259

Reaktionsgleichung

Reaktionsgleichung von HRID 1606259
[C:1]([NH:4][C:5](C1SC=CC=1)([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1C)[C:6]([OH:8])=[O:7])(=[O:3])[CH3:2]>[Ni].CC(C)=O>[C:1]([NH:4][CH:5]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:6]([OH:8])=[O:7])(=[O:3])[CH3:2]

Komponenten

4

Edukt 1

HCID 86733267HCID 86733267, Verbindung

Produkt 1

HCID 85935N-Acetyl-DL-phenylglycineAusbeute 73 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 180AcetoneLösungsmittel

Versuchsvorschrift

Two (2.0) cc of Raney nickel (WII) was suspended in 15 ml of acetone, and refluxed for 7 minutes. Cooling the suspension to room temperature, 315 mg of α-acetylamino-α-tolylthiophenylacetic acid was added, followed by 5.5 hours' stirring at room temperature. The insoluble matter was separated by filtration, and washed with ethanol. The filtrate and washing were combined and concentrated under reduced pressure. The residue was crystallized from an ether-n-hexane system. Thus 141 mg of α-acetylaminophenylacetic acid was obtained. The yield was 73%.

Aufarbeitung

  1. temperaturerefluxed for 7 minutes
  2. customThe insoluble matter was separated by filtration
  3. washwashed with ethanol
  4. washThe filtrate and washing
  5. concentrationconcentrated under reduced pressure
  6. customThe residue was crystallized from an ether-n-hexane system

Quellen und Nachweise

ORD-Eintrag
ord-386f7d6536084da18b1ad9a9baae91ff
Quelldatensatz
uspto-grants-1976_04
Patentnummer
US03952044

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