Benzyl Bromide → 3-Cyclopropylmethylamino-4-chloro-5-methylsulfinylbenzoic acid
Reaktionsgleichung
[Cl:1][C:2]1[CH:3]=[C:4](N)[C:5](=[CH:9][C:10]=1[S:11]([CH3:14])(=[O:13])=O)[C:6]([OH:8])=[O:7].C(Br)C1C=CC=CC=1.[NH2:24][C:25]1[CH:26]=[C:27]([CH:31]=C(S(C)=O)C=1Cl)C(O)=O.C1(CBr)CC1>>[CH:26]1([CH2:25][NH:24][C:3]2[CH:4]=[C:5]([CH:9]=[C:10]([S:11]([CH3:14])=[O:13])[C:2]=2[Cl:1])[C:6]([OH:8])=[O:7])[CH2:27][CH2:31]1Komponenten
5
Versuchsvorschrift
This product is prepared by replacing the 4-chloro-5-methylsulfonylanthranilic acid and the benzyl bromide employed in Example 4 by equivalent quantities of 3-amino-4-chloro-5-methylsulfinylbenzoic acid and cyclopropylmethyl bromide, respectively and following substantially the same procedure described in Example 4.