2-(beta-Hydroxyethyl)amino-6-(beta-hydroxyethyl)amino-4-chloronitrobenzene → 2-(beta-Hydroxyethyl)amino-6-(beta-hydroxyethyl)amino-4-(beta-aminoethyl)aminonitrobenzene

HRID 1606858Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1606858
[OH:1][CH2:2][CH2:3][NH:4][C:5]1[CH:10]=[C:9](Cl)[CH:8]=[C:7]([NH:12][CH2:13][CH2:14][OH:15])[C:6]=1[N+:16]([O-:18])=[O:17]>C(N)CN>[OH:1][CH2:2][CH2:3][NH:4][C:5]1[CH:10]=[C:9]([NH:4][CH2:5][CH2:6][NH2:16])[CH:8]=[C:7]([NH:12][CH2:13][CH2:14][OH:15])[C:6]=1[N+:16]([O-:18])=[O:17]

Komponenten

3

Edukt 1

HCID 200710912-(beta-Hydroxyethyl)amino-6-(beta-hydroxyethyl)amino-4-chloronitrobenzene

Produkt 1

HCID 198511702-(beta-Hydroxyethyl)amino-6-(beta-hydroxyethyl)amino-4-(beta-aminoethyl)aminonitrobenzene

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3301EthylenediamineLösungsmittel

Versuchsvorschrift

0.13 mole (36.5 g) of 2-(β-hydroxyethyl)amino-6-(β-hydroxyethyl)amino-4-chloronitrobenzene, whose synthesis was described in stage 1 of example 2, was heated for 2 hours at 130° C. in 150 ml of ethylenediamine, then the reaction medium diluted with 450 ml of ice water to precipitate out the desired product. After filtering and water washing to neutrality, the product obtained was dried under vacuum in the presence of P2O5. It was recrystallized from 96° ethanol and melted at 220° C.

Aufarbeitung

  1. customthe reaction
  2. customto precipitate out the desired product
  3. filtrationAfter filtering
  4. customwater washing to neutrality, the product obtained
  5. dry with materialwas dried under vacuum in the presence of P2O5
  6. customIt was recrystallized from 96° ethanol and melted at 220° C.

Quellen und Nachweise

ORD-Eintrag
ord-a1373ab1801340939b767731612b3c47
Quelldatensatz
uspto-grants-1989_09
Patentnummer
US04863482

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