O-((2E)-3-Chloro-2-propen-1-yl)hydroxylamine → 2-[(E)-N-(3-chloroprop-2-enoxy)-C-ethylcarbonimidoyl]-5-(2-methylpyrazol-3-yl)cyclohexane-1,3-dione

HRID 1606866Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1606866
[CH3:1][N:2]1[C:6]([CH:7]2[CH2:12][C:11](=[O:13])[CH:10]([C:14](=O)[CH2:15][CH3:16])[C:9](=[O:18])[CH2:8]2)=[CH:5][CH:4]=[N:3]1.[Cl:19]/[CH:20]=[CH:21]/[CH2:22][O:23][NH2:24]>>[Cl:19][CH:20]=[CH:21][CH2:22][O:23]/[N:24]=[C:14](/[CH:10]1[C:11](=[O:13])[CH2:12][CH:7]([C:6]2[N:2]([CH3:1])[N:3]=[CH:4][CH:5]=2)[CH2:8][C:9]1=[O:18])\[CH2:15][CH3:16]

Komponenten

3

Edukt 2

HCID 158058O-((2E)-3-Chloro-2-propen-1-yl)hydroxylamineHCID 145362755-(1-methyl-1H-pyrazol-5-yl)-2-propionylcyclohexane-1,3-dione

Produkt 1

HCID 1415602412-[(E)-N-(3-chloroprop-2-enoxy)-C-ethylcarbonimidoyl]-5-(2-methylpyrazol-3-yl)cyclohexane-1,3-dione

Versuchsvorschrift

To 5 ml of an ethanolic solution of 0.35 g (1.4 mmols) of 5-(1-methyl-1H-pyrazol-5-yl)-2-propionylcyclohexane-1,3-dione was added 3.8 ml (1.4 mmols) of 0.38 mol ethanolic solution of (E)-3-chloro-2-propenyloxyamine. The mixture was reacted for 10 hours with stirring. After completion of the reaction, the reaction mixture was concentrated under reduced pressure. The resulting crude product was purified by silica gel column chromatography (hexane:ethyl acetate=b 1:2) to give 0.25 g of the product.

Aufarbeitung

  1. customThe mixture was reacted for 10 hours
  2. customAfter completion of the reaction
  3. concentrationthe reaction mixture was concentrated under reduced pressure
  4. customThe resulting crude product was purified by silica gel column chromatography (hexane:ethyl acetate=b 1:2)

Quellen und Nachweise

ORD-Eintrag
ord-5531e9712f6d42a1ab5f13ad87a3c89a
Quelldatensatz
uspto-grants-1989_09
Patentnummer
US04863504

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