Thionyl Chloride → 2-Bromomethylbenzoyl chloride

HRID 1606897

Reaktionsgleichung

Reaktionsgleichung von HRID 1606897
[Br:1][CH2:2][C:3]1[C:4]([C:9]([OH:11])=O)=[CH:5][CH:6]=[CH:7][CH:8]=1.S(Cl)([Cl:14])=O>C1C=CC=CC=1.CN(C=O)C>[Br:1][CH2:2][C:3]1[C:4]([C:9]([Cl:14])=[O:11])=[CH:5][CH:6]=[CH:7][CH:8]=1

Komponenten

5

Edukt 2

HCID 24386Thionyl ChlorideHCID 3460032-(Bromomethyl)benzoic acid

Produkt 1

HCID 122516322-Bromomethylbenzoyl chloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6228DimethylformamideKatalysatorHCID 241BenzeneLösungsmittel

Versuchsvorschrift

--A solution of α-bromotoluic acid (1.08 g) in dry benzene (10 ml) was stirred for 2 hours with thionyl chloride (0.73 ml) and dry DMF (five drops). The reaction mixture was evaporated to dryness, taken up in toluene and evaporated again. The crude product was crystallized from n-hexane (10 ml, charcoal) thereby obtaining pure α-bromotoluic acid chloride (0.95 g) as white flakes.

Aufarbeitung

  1. customThe reaction mixture was evaporated to dryness
  2. customevaporated again
  3. customThe crude product was crystallized from n-hexane (10 ml, charcoal)

Quellen und Nachweise

ORD-Eintrag
ord-a9975bce2bb948979e1ab38e7d6a5308
Quelldatensatz
uspto-grants-1989_09
Patentnummer
US04863914

Verknüpfte Notizen

Wird geladen…