Sodium Hydroxide → 3-[3-(5-Bromo-3-methylpyrid-2-yl)propyl]-6-(3-pyridylmethyl)-3H-1,2,3-triazolo[5,4-b]pyridine

HRID 1607049

Reaktionsgleichung

Reaktionsgleichung von HRID 1607049
[N:1]([O-])=O.[Na+].[Br:5][C:6]1[CH:7]=[C:8]([CH3:30])[C:9]([CH2:12][CH2:13][CH2:14][NH:15][C:16]2[C:21]([NH2:22])=[CH:20][C:19]([CH2:23][C:24]3[CH:25]=[N:26][CH:27]=[CH:28][CH:29]=3)=[CH:18][N:17]=2)=[N:10][CH:11]=1.[OH-].[Na+]>S(=O)(=O)(O)O>[Br:5][C:6]1[CH:7]=[C:8]([CH3:30])[C:9]([CH2:12][CH2:13][CH2:14][N:15]2[C:16]3=[N:17][CH:18]=[C:19]([CH2:23][C:24]4[CH:25]=[N:26][CH:27]=[CH:28][CH:29]=4)[CH:20]=[C:21]3[N:22]=[N:1]2)=[N:10][CH:11]=1

Komponenten

5

Edukt 3

HCID 14798Sodium HydroxideHCID 198517762-[3-(5-Bromo-3-methylpyrid-2-yl)-propylamino]-3-amino-5-(pyrid-3-ylmethyl)pyridineHCID 23668193Sodium Nitrite

Produkt 1

HCID 198517903-[3-(5-Bromo-3-methylpyrid-2-yl)propyl]-6-(3-pyridylmethyl)-3H-1,2,3-triazolo[5,4-b]pyridineAusbeute 57 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1118Sulfuric AcidLösungsmittel

Versuchsvorschrift

Sodium nitrite solution (1.02 g in 50 ml water) was added dropwise over 25 minutes to a stirred and cooled solution of 2-[3-(5-bromo-3-methylpyrid-2-yl)-propylamino]-3-amino-5-(pyrid-3-ylmethyl)pyridine (4.7 g) in sulphuric acid (molar, 200 ml) keeping the temperature at 4° C. Reaction was stirred at 4° C. for a further hour and was then left in the fridge overnight and then warmed to room temperature. The reaction mixture was basified to pH 13 with sodium hydroxide solution (10 M). Chloroform extraction of the reaction mixture gave the crude product which was then chromatographed on silica in methanol/chloroform 1:19 and then recrystallised from acetonitrile to give the title compound (2.75 g), m.p. 109°-110° C.

Aufarbeitung

  1. customat 4° C
  2. customReaction
  3. stirringwas stirred at 4° C. for a further hour
  4. extractionChloroform extraction of the reaction mixture
  5. customgave the crude product which
  6. customwas then chromatographed on silica in methanol/chloroform 1:19
  7. customrecrystallised from acetonitrile

Quellen und Nachweise

ORD-Eintrag
ord-235d2c5d355c42e8930c9cc34fd311f8
Quelldatensatz
uspto-grants-1989_09
Patentnummer
US04863933

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