Trifluoroacetic acid → HCID 11552535, Verbindung

HRID 16072Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 16072
[Cl:1][C:2]1[CH:3]=[C:4]([C:11]2[CH:16]=[C:15]([Cl:17])[CH:14]=[CH:13][C:12]=2[O:18][CH2:19][C:20]([O:22]C(C)(C)C)=[O:21])[CH:5]=[CH:6][C:7]=1[S:8]([CH3:10])=[O:9].C(O)(C(F)(F)F)=[O:28]>>[Cl:1][C:2]1[CH:3]=[C:4]([C:11]2[CH:16]=[C:15]([Cl:17])[CH:14]=[CH:13][C:12]=2[O:18][CH2:19][C:20]([OH:22])=[O:21])[CH:5]=[CH:6][C:7]=1[S:8]([CH3:10])(=[O:9])=[O:28]

Komponenten

3

Edukt 2

HCID 6422Trifluoroacetic acidHCID 866203721,1-Dimethylethyl [[3',5-dichloro-4'-(methylsulfinyl)[1,1'-biphenyl]-2-yl]oxy]acetate

Produkt 1

HCID 11552535HCID 11552535, Verbindung

Versuchsvorschrift

A solution of the product from step d) (73 mg) in TFA (3 ml) was stirred for 2 h. The solvent was removed in vacuo, water was added and the mixture was extracted with dichloromethane (three times). The organic extracts were dried (MgSO4), evaporated and triturated with ether to give the title compound (46 mg) as a white solid. M.p. 140-2° C.

Aufarbeitung

  1. customThe solvent was removed in vacuo, water
  2. additionwas added
  3. extractionthe mixture was extracted with dichloromethane (three times)
  4. dry with materialThe organic extracts were dried (MgSO4)
  5. customevaporated
  6. customtriturated with ether

Quellen und Nachweise

ORD-Eintrag
ord-4d43f8afcb5d4b9f9222be483f1f66a8
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07737135B2

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