2-(Dimethylamino)ethanol → 6-(2-Dimethylaminoethoxy)imidazo[1,2-b]pyridazine

HRID 1607306

Reaktionsgleichung

Reaktionsgleichung von HRID 1607306
[Na].Cl[C:3]1[CH:4]=[CH:5][C:6]2[N:7]([CH:9]=[CH:10][N:11]=2)[N:8]=1.[CH3:12][N:13]([CH3:17])[CH2:14][CH2:15][OH:16]>>[CH3:12][N:13]([CH3:17])[CH2:14][CH2:15][O:16][C:3]1[CH:4]=[CH:5][C:6]2[N:7]([CH:9]=[CH:10][N:11]=2)[N:8]=1

Komponenten

4

Edukt 3

HCID 79022-(Dimethylamino)ethanolHCID 138828Imidazo(1,2-b)pyridazine, 6-chloro-HCID 5360545Sodium

Produkt 1

HCID 200766166-(2-Dimethylaminoethoxy)imidazo[1,2-b]pyridazine

Reaktionsbedingungen

Temperatur
130 °C

Versuchsvorschrift

Sodium metal (0.25 g) and 6-chloroimidazo[1,2-b]pyridazine are added to 25 ml of 2-dimethylaminoethanol and the mixture is heated in a sealed tube for 3 hours at 130° C. After cooling, the solvent is evaporated and the residue is treated with water and extracted with methylene chloride. The organic layer is separated, washed with saturated sodium chloride solution and dried over MgSO4. Evaporation of the solvent gives the title compound as a viscous oil which solidified on standing. The yield is 2.5 g.

Aufarbeitung

  1. temperatureAfter cooling
  2. customthe solvent is evaporated
  3. additionthe residue is treated with water
  4. extractionextracted with methylene chloride
  5. customThe organic layer is separated
  6. washwashed with saturated sodium chloride solution
  7. dry with materialdried over MgSO4
  8. customEvaporation of the solvent

Quellen und Nachweise

ORD-Eintrag
ord-00ffed7e2ede4aa993b9ae90c719b3c0
Quelldatensatz
uspto-grants-1989_09
Patentnummer
US04864022

Verknüpfte Notizen

Wird geladen…