Thionyl Chloride → 2-Methyl-2-(4-pyridinylthio)propanoyl chloride

HRID 1607532Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1607532
[CH3:1][C:2]([S:7][C:8]1[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=1)([CH3:6])[C:3](O)=[O:4].S(Cl)([Cl:16])=O>>[CH3:1][C:2]([S:7][C:8]1[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=1)([CH3:6])[C:3]([Cl:16])=[O:4]

Komponenten

3

Edukt 2

HCID 24386Thionyl ChlorideHCID 135191122-Methyl-2-(4-pyridinylthio)propionic acid

Produkt 1

HCID 145999382-Methyl-2-(4-pyridinylthio)propanoyl chloride

Versuchsvorschrift

9.7 g of the product from step (b) was refluxed for 2 1/2 hours in 225 ml thionyl chloride. The mixture was concentrated in vacuo. The residue was triturated and concentrated in vacuo two times with toluene to yield a white solid which showed the expected carbonyl shift in the IR, indicative of an acid chloride.

Aufarbeitung

  1. concentrationThe mixture was concentrated in vacuo
  2. customThe residue was triturated
  3. concentrationconcentrated in vacuo two times with toluene
  4. customto yield a white solid which

Quellen und Nachweise

ORD-Eintrag
ord-5985fda140f3428596db54047ef9ad24
Quelldatensatz
uspto-grants-1989_09
Patentnummer
US04866068

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