Tetrahydrofuran → Ethoxyprecocene

HRID 1607653Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1607653
O1CCC[CH2:2]1.[H-].[Al+3].[Li+].[H-].[H-].[H-].[CH3:12][O:13][C:14]1[CH:15]=[C:16]2[C:21](=[CH:22][C:23]=1[O:24][CH3:25])[O:20][C:19]([CH3:27])([CH3:26])[CH2:18][C:17]2=O>>[CH3:12][O:13][C:14]1[CH:15]=[C:16]2[C:21](=[CH:22][C:23]=1[O:24][CH2:25][CH3:2])[O:20][C:19]([CH3:27])([CH3:26])[CH:18]=[CH:17]2

Komponenten

4

Edukt 3

HCID 8028TetrahydrofuranHCID 1033734H-1-Benzopyran-4-one, 2,3-dihydro-6,7-dimethoxy-2,2-dimethyl-HCID 21226445Aluminium lithium hydride

Produkt 1

HCID 127846EthoxyprecoceneAusbeute 88 %

Versuchsvorschrift

In 80 ml of anhydrous tetrahydrofurane 5.0 g (20 millimoles) of 6-methoxy-7-methoxy-2,2-dimethyl-4-chromanone are dissolved whereupon 1.5 g of lithium aluminum hydride are added in small portions under stirring and the reaction mixture is heated to boiling for an hour. The reaction mixture is worked up according to Example 31. The product is purified by column chromatography. Thus 4.1 g of the desired compound are obtained in the form of a colorless oil, yield 88%.

Aufarbeitung

  1. additionare added in small portions
  2. temperaturethe reaction mixture is heated
  3. waitto boiling for an hour
  4. customThe product is purified by column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-9a53fcbe4a39471b82e18eec502761f5
Quelldatensatz
uspto-grants-1989_09
Patentnummer
US04866089

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