2,6-Diisopropylphenyl isocyanate → 1-Chroman-3-yl-3-(2,6-diisopropyl-phenyl)-urea

HRID 1607926Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1607926
[NH2:1][CH:2]1[CH2:7][C:6]2[CH:8]=[CH:9][CH:10]=[CH:11][C:5]=2[O:4][CH2:3]1.[CH3:12][CH:13]([C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([CH:21]([CH3:23])[CH3:22])[C:16]=1[N:24]=[C:25]=[O:26])[CH3:14]>C(OCC)(=O)C>[CH3:14][CH:13]([C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([CH:21]([CH3:22])[CH3:23])[C:16]=1[NH:24][C:25]([NH:1][CH:2]1[CH2:7][C:6]2[CH:8]=[CH:9][CH:10]=[CH:11][C:5]=2[O:4][CH2:3]1)=[O:26])[CH3:12]

Komponenten

4

Edukt 2

HCID 922592,6-Diisopropylphenyl isocyanateHCID 2057093,4-Dihydro-3-amino-2H-1-benzopyran

Produkt 1

HCID 145552481-Chroman-3-yl-3-(2,6-diisopropyl-phenyl)-ureaAusbeute 59,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To a solution of 3,4-dihydro-3-amino-2H-benzopyran (0.9 g, 6 mmole) in 50 ml of ethyl acetate, there was added 1.22 g (6 mmol) of 2,6-bis(1-methylethyl)phenyl isocyanate. The resulting mixture was stirredat room temperature for twenty hours. The solvent was removed under vacuum and the residue was suspended in 20% ethyl acetate/hexane. The precipitated solid was collected by filtration and dried to yield 1.25 g of N-[2,6-bis(1-methylethyl)phenyl]-N'-(3,4-dihydro-2H-benzopyran-3-yl)urea, mp 186°-188° C.

Aufarbeitung

  1. waitThe resulting mixture was stirredat room temperature for twenty hours
  2. customThe solvent was removed under vacuum
  3. filtrationThe precipitated solid was collected by filtration
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-fdf2a7480eb9486584f57f10126f4f10
Quelldatensatz
uspto-grants-1989_09
Patentnummer
US04868210

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