Hydrochloric Acid → Methyl (4-chloro-2-iodophenoxy)acetate
Reaktionsgleichung
Cl[C:2]1[CH:3]=[CH:4][C:5]([I:9])=[C:6]([OH:8])[CH:7]=1.Br[CH2:11][C:12]([O:14][CH3:15])=[O:13].C(=O)([O-])[O-].[K+].[K+].[ClH:22]>C(#N)C>[Cl:22][C:3]1[CH:2]=[CH:7][C:6]([O:8][CH2:11][C:12]([O:14][CH3:15])=[O:13])=[C:5]([I:9])[CH:4]=1Komponenten
6
Edukt 4
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A mixture of 5-chloro-2-iodophenol (4.95 g), methyl bromoacetate (1.85 ml) and potassium carbonate (2.79 g) in acetonitrile (20 ml) was heated under reflux for 2 h. Aq HCl was added and the mixture was extracted with ether (three times). The organic extracts were dried (MgSO4), evaporated and purified by chromatography (silica, petrol ether as eluent) to give the sub-title compound (5.75 g).
Aufarbeitung
- temperaturewas heated
- temperatureunder reflux for 2 h
- extractionthe mixture was extracted with ether (three times)
- dry with materialThe organic extracts were dried (MgSO4)
- customevaporated
- custompurified by chromatography (silica, petrol ether as eluent)
Quellen und Nachweise
- ORD-Eintrag
- ord-ff8cd44555e645b4b5e07ae7d5a0b751
- Quelldatensatz
- uspto-grants-2010_06
- Patentnummer
- US07737135B2
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