Sodium Hydroxide → 2-Aminomethyl-4-(4-fluorobenzyl)morpholine

HRID 1608211Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1608211
C([NH:4][CH2:5][CH:6]1[O:11][CH2:10][CH2:9][N:8]([CH2:12][C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)[CH2:7]1)(=O)C.[OH-].[Na+]>Cl>[NH2:4][CH2:5][CH:6]1[O:11][CH2:10][CH2:9][N:8]([CH2:12][C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)[CH2:7]1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 10683176N-({4-[(4-Fluorophenyl)methyl]morpholin-2-yl}methyl)acetamide

Produkt 1

HCID 102427352-Aminomethyl-4-(4-fluorobenzyl)morpholine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel

Versuchsvorschrift

A solution of 2-acetylaminomethyl-4-(4-fluorobenzyl)morpholine (3.0 g) in 10% hydrochloric acid (50 ml) is refluxed with stirring for 4 hours. The reaction mixture is adjusted to pH 11 with aqueous sodium hydroxide solution and extracted with chloroform. The organic layer is washed successively with water and saturated aqueous sodium chloride solution, and dried over magnesium sulfate. Removal of the solvent under reduced pressure gives the title compound as an oil.

Aufarbeitung

  1. extractionextracted with chloroform
  2. washThe organic layer is washed successively with water and saturated aqueous sodium chloride solution
  3. dry with materialdried over magnesium sulfate
  4. customRemoval of the solvent under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-5294a44b751645709e9b69ea735d3844
Quelldatensatz
uspto-grants-1989_09
Patentnummer
US04870074

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