4-(2-Chlorobenzyl)-2-chloromethyl-6-methylmorpholine → N-[[4-(2-chlorobenzyl)-6-methyl-2-morpholinyl]methyl]phthalimide

HRID 1608226Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1608226
[Cl:1][C:2]1[CH:17]=[CH:16][CH:15]=[CH:14][C:3]=1[CH2:4][N:5]1[CH2:10][CH:9]([CH3:11])[O:8][CH:7]([CH2:12]Cl)[CH2:6]1.[K].[C:19]1(=[O:29])[NH:23][C:22](=[O:24])[C:21]2=[CH:25][CH:26]=[CH:27][CH:28]=[C:20]12>CN(C)C=O>[Cl:1][C:2]1[CH:17]=[CH:16][CH:15]=[CH:14][C:3]=1[CH2:4][N:5]1[CH2:10][CH:9]([CH3:11])[O:8][CH:7]([CH2:12][N:23]2[C:22](=[O:24])[C:21]3=[CH:25][CH:26]=[CH:27][CH:28]=[C:20]3[C:19]2=[O:29])[CH2:6]1

Komponenten

4

Edukt 2

HCID 198486194-(2-Chlorobenzyl)-2-chloromethyl-6-methylmorpholineHCID 24194345Phthalimide potassium salt

Produkt 1

HCID 19848602N-[[4-(2-chlorobenzyl)-6-methyl-2-morpholinyl]methyl]phthalimideAusbeute 94 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
150 °C

Versuchsvorschrift

A mixture of 4-(2-chlorobenzyl)-2-chloromethyl-6-methylmorpholine (19.7 g), phthalimide potassium salt (14.6 g), and dimethylformamide (150 ml) is stirred at 150° C. for 5 hours. The reaction mixture is poured into ice-water and extracted with diethyl ether. The organic layer is washed successively with water and saturated aqueous sodium chloride solution, and dried over magnesium sulfate. The solvent is distilled off to give the title compound (26 g) as an oil.

Aufarbeitung

  1. extractionextracted with diethyl ether
  2. washThe organic layer is washed successively with water and saturated aqueous sodium chloride solution
  3. dry with materialdried over magnesium sulfate
  4. distillationThe solvent is distilled off

Quellen und Nachweise

ORD-Eintrag
ord-b4daf0cac8694cad8489942fe69d50af
Quelldatensatz
uspto-grants-1989_09
Patentnummer
US04870074

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