Hydrochloride methanol → 5-[3-(Amino)propylamino]imidazo[1,2-a]pyridine dihydrochloride

HRID 1608590

Reaktionsgleichung

Reaktionsgleichung von HRID 1608590
C(OC([NH:8][CH2:9][CH2:10][CH2:11][NH:12][C:13]1[N:18]2[CH:19]=[CH:20][N:21]=[C:17]2[CH:16]=[CH:15][CH:14]=1)=O)(C)(C)C.[ClH:22].CO>C(Cl)Cl>[ClH:22].[ClH:22].[NH2:8][CH2:9][CH2:10][CH2:11][NH:12][C:13]1[N:18]2[CH:19]=[CH:20][N:21]=[C:17]2[CH:16]=[CH:15][CH:14]=1

Komponenten

4

Edukt 2

HCID 21893726Hydrochloride methanolHCID 23362879Carbamic acid,[3-(imidazo[1,2-a]pyridin-5-ylamino)propyl]-,1,1-dimethylethyl ester

Produkt 1

HCID 200866655-[3-(Amino)propylamino]imidazo[1,2-a]pyridine dihydrochlorideAusbeute 83 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a suspension of 5-[3-(tert-butoxycarbonylamino)propylamino]imidazo[1,2-a]pyridine (1.742 g, 6 mmoles) in methylene chloride (40 ml) was added hydrogen chloride-methanol (6 ml) and the mixture was stirred at room temperature for 20 hours. After the solvent was distilled off, ethanol (15 ml) and ether (30 ml) were added to the residue. Then, the crystals precipitated were filtered off and washed in turn with ether and a small amount of ethanol to obtain 1.311 g of the desired product (83.0%, pale yellow crystals).

Aufarbeitung

  1. distillationAfter the solvent was distilled off
  2. additionethanol (15 ml) and ether (30 ml) were added to the residue
  3. customThen, the crystals precipitated
  4. filtrationwere filtered off
  5. washwashed in turn with ether

Quellen und Nachweise

ORD-Eintrag
ord-4047a10adb9b4e57b56f5bb839a4179f
Quelldatensatz
uspto-grants-1995_03
Patentnummer
US05395839

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