5-[2-(Amino)ethylthio]imidazo[1,2-a]pyridine dihydrochloride → 5-[2-(Amino)ethylthio]imidazo[1,2-a]pyridine

HRID 1608636

Reaktionsgleichung

Reaktionsgleichung von HRID 1608636
Cl.Cl.[NH2:3][CH2:4][CH2:5][S:6][C:7]1[N:12]2[CH:13]=[CH:14][N:15]=[C:11]2[CH:10]=[CH:9][CH:8]=1>C(Cl)(Cl)Cl>[NH2:3][CH2:4][CH2:5][S:6][C:7]1[N:12]2[CH:13]=[CH:14][N:15]=[C:11]2[CH:10]=[CH:9][CH:8]=1

Komponenten

3

Edukt 1

HCID 233628335-[2-(Amino)ethylthio]imidazo[1,2-a]pyridine dihydrochloride

Produkt 1

HCID 152293695-[2-(Amino)ethylthio]imidazo[1,2-a]pyridineAusbeute 99,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

After a suspension of 5-[2(amino)ethylthio]imidazo-[1,2-a]pyridine dihydrochloride (13.31 g, 50 mmloes) in chloroform (200 ml) was washed with 3N sodium hydroxide (50 ml), the aqueous layer was extracted with chloroform, the combined chloroform layer was dried over anhydrous magnesium sulfate. Then, the solvent was distilled off to obtain 9.63 g of the desired product (99.7%, pale yellow oily product).

Aufarbeitung

  1. washwas washed with 3N sodium hydroxide (50 ml)
  2. extractionthe aqueous layer was extracted with chloroform
  3. dry with materialthe combined chloroform layer was dried over anhydrous magnesium sulfate
  4. distillationThen, the solvent was distilled off

Quellen und Nachweise

ORD-Eintrag
ord-74624a2a1b5b49229391bdcce7eb0e9a
Quelldatensatz
uspto-grants-1995_03
Patentnummer
US05395839

Verknüpfte Notizen

Wird geladen…