Sodium Hydroxide → 2-[2-[3-[2-[4-(Cyclobutyl)-2-thiazolyl]ethenyl]phenylamino]-2-oxoethyl]benzoic acid sodium salt

HRID 1609342Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1609342
[CH:1]1([C:5]2[N:6]=[C:7](/[CH:10]=[CH:11]/[C:12]3[CH:13]=[C:14]([NH:18][C:19](=[O:30])[CH2:20][C:21]4[CH:29]=[CH:28][CH:27]=[CH:26][C:22]=4[C:23]([OH:25])=[O:24])[CH:15]=[CH:16][CH:17]=3)[S:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1.[OH-].[Na+:32]>C(O)C>[Na+:32].[CH:1]1([C:5]2[N:6]=[C:7]([CH:10]=[CH:11][C:12]3[CH:13]=[C:14]([NH:18][C:19](=[O:30])[CH2:20][C:21]4[CH:29]=[CH:28][CH:27]=[CH:26][C:22]=4[C:23]([O-:25])=[O:24])[CH:15]=[CH:16][CH:17]=3)[S:8][CH:9]=2)[CH2:2][CH2:3][CH2:4]1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 20084337(E)-2-[2-[3-[2-[4-(cyclobutyl)-2-thiazolyl]ethenyl]phenylamino]-2-oxoethyl]benzoic acid

Produkt 1

HCID 773591692-[2-[3-[2-[4-(Cyclobutyl)-2-thiazolyl]ethenyl]phenylamino]-2-oxoethyl]benzoic acid sodium salt

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of 0.418 g of (E)-2-[2-[3-[2-[4-(cyclobutyl)-2-thiazolyl]ethenyl]phenylamino]-2-oxoethyl]benzoic acid in 10 ml of ethyl alcohol was mixed at room temperature with 5.0 ml of 0.2N sodium hydroxide solution. This mixture was warmed on a steam bath until all the solids had solubilized. After cooling the reaction mixture was condensed in vacuo at 40° C. to constant weight to yield E)-2-[2-[3-[2-[4-(cyclobutyl)-2-thiazolyl]ethenyl]phenylamino]-2-oxoethyl]benzoic acid sodium salt as a white solid.

Aufarbeitung

  1. temperatureThis mixture was warmed on a steam bath until all the solids
  2. temperatureAfter cooling the reaction mixture
  3. customcondensed in vacuo at 40° C. to constant weight

Quellen und Nachweise

ORD-Eintrag
ord-f503bd6b3e1b40d686f9095ecb5f9e93
Quelldatensatz
uspto-grants-1995_03
Patentnummer
US05399702

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