Hydrochloric Acid → Isopropyl 1-methyl-3-indoleacetimidate hydrochloride

Beteiligte Stoffe

Reaktionsschritte

Hydrogen chloride was bubbled through a stirred solution of 7.5 g (44 mmol) of 1-methylindole-3-acetonitrile in 100ml of dry isopropanol at room temperature. After 4 hours, the solvent was removed under reduced pressure and the residue was triturated with diethyl ether to give 5.17 g (44%) of isopropyl 1-methyl-3-indoleacetimidate hydrochloride as a white solid of melting point 133° C.

Herkunft & Nachweise