Anthranilic Acid → N-Phenylanthranilic Acid

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Anthranilic Acid	HCID 227	—
Edukt	2-Bromo-4-methyl-1-nitrobenzene	HCID 8167038	—
Produkt	N-Phenylanthranilic Acid	HCID 4386	—

Reaktionsschritte

As shown in Scheme 7, coupling of 3-bromo-4-nitrotoluene with 2-amino-benzoic acid via an Ullmann reaction yields an N-phenyl-anthranilic acid. After protection of the acid with 2-amino-2-methyl-1-propanol, oxidation affords the corresponding aldehyde. Addition of vinyl magnesium bromide and deprotection provides the N-phenyl-anthranilic acid containing a latent Michael acceptor. ##STR15##

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US05399790
Quelldatensatz	uspto-grants-1995_03
ORD ID	ord-920e207501f64dc5941e0fe889c060c3
Quellennotiz	uspto-grants-1995_03