Hydrazine → 2-Buten-1-amine, 4-[3-(1-piperidinylmethyl)phenoxy]-, (E)-

HRID 1609464

Reaktionsgleichung

Reaktionsgleichung von HRID 1609464
Cl[CH2:2]/[CH:3]=[CH:4]/[CH2:5][N:6]1[C:10](=O)[C:9]2=[CH:12][CH:13]=[CH:14][CH:15]=[C:8]2[C:7]1=O.[N:17]1([CH2:23][C:24]2[CH:25]=[C:26]([OH:30])C=CC=2)CCCCC1.NN>>[N:6]1([CH2:7][C:8]2[CH:15]=[C:14]([CH:13]=[CH:12][CH:9]=2)[O:30][CH2:26]/[CH:25]=[CH:24]/[CH2:23][NH2:17])[CH2:10][CH2:2][CH2:3][CH2:4][CH2:5]1

Komponenten

4

Edukt 3

HCID 9321HydrazineHCID 8269741-(3-Hydroxybenzyl)piperidineHCID 57093742-((2E)-4-chlorobut-2-en-1-yl)-2,3-dihydro-1H-isoindole-1,3-dione

Produkt 1

HCID 131044202-Buten-1-amine, 4-[3-(1-piperidinylmethyl)phenoxy]-, (E)-

Versuchsvorschrift

In the same manner as in Example 1, the N-[4-chloro(trans) 2-butenyl]phthalimide was reacted with 3-(1-piperidinomethyl)phenol, followed by hydrolysis with hydrazine to obtain 1.56 g of 4-[3-(1-piperidinomethyl)phenoxy]-(trans) 2-butenylamine. To a solution of 1 g of this amine compound in 30 ml of chloroform was added 0.9 g of the 3-chloro-4-methyl-1,2,4-benzothiadiazine-1,1-dioxide, followed by the same treatment as in Example 1 to obtain 1.57 g of white crystalline 3-[N-[4-[3-(1-piperidinomethyl)phenoxy]-(trans) 2-butenyl]amino]-4-methyl-1,2,4-benzothiadiazine-1,1-dioxide (compound 23, yield 90% ). M.p. 116°~120° C.

Quellen und Nachweise

ORD-Eintrag
ord-313d388b41c2482282c1932b88579375
Quelldatensatz
uspto-grants-1995_03
Patentnummer
US05401739

Verknüpfte Notizen

Wird geladen…