5-Methyl-2-(trifluoromethyl)-3-furancarboxylic acid → 2-Methyl-5-(trifluoromethyl)furan

HRID 1610327Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1610327
[CH3:1][C:2]1[O:6][C:5]([C:7]([F:10])([F:9])[F:8])=[C:4](C(O)=O)[CH:3]=1>N1C2C(=CC=CC=2)C=CC=1.S([O-])([O-])(=O)=O.[Cu+].[Cu+]>[CH3:1][C:2]1[O:6][C:5]([C:7]([F:10])([F:9])[F:8])=[CH:4][CH:3]=1

Komponenten

4

Edukt 1

HCID 27821835-Methyl-2-(trifluoromethyl)-3-furancarboxylic acid

Produkt 1

HCID 109536882-Methyl-5-(trifluoromethyl)furanAusbeute 54 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 134737Sulfuric acid, copper(1+) salt (1:2)KatalysatorHCID 7047QuinolineLösungsmittel

Versuchsvorschrift

To a solution of 5-methyl-2-(trifluoromethyl)-3-furancarboxylic acid (20 g, 103 mmol) in quinoline (36 ml) was added copper (I) sulfate (1 g, 6.3 mmol). While bubbling nitrogen, the mixture was immersed in an oil bath at 230° C. until gas generation ceased. The generated gas was collected and distilled again to give 2-methyl-5-(trifluoromethyl)furan (8.34 g, 54%).

Aufarbeitung

  1. customWhile bubbling nitrogen
  2. customthe mixture was immersed in an oil bath at 230° C. until gas generation
  3. customThe generated gas was collected
  4. distillationdistilled again

Quellen und Nachweise

ORD-Eintrag
ord-1ad3a181e7444430b968eb54d685f291
Quelldatensatz
uspto-grants-2006_01
Patentnummer
US06982348B2

Notizen zur Reaktion

Wird geladen…