(2S)-2-[[4'-[[(1,1-dimethylethyl)amino]carbonyl]-3'-fluoro-5-(trifluoromethyl) [1,1'-biphenyl]-2-yl]oxy]-propanoic acid → (2S)-2-[[5-chloro-4'-[[(1,1-dimethylethyl)amino]carbonyl]-3'-fluoro[1,1'-biphenyl]-2-yl]oxy]-propanoic acid

HRID 16112

Reaktionsgleichung

Reaktionsgleichung von HRID 16112
[CH3:1][C:2]([NH:5][C:6]([C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[C:18](C(F)(F)F)[CH:17]=[CH:16][C:15]=2[O:24][C@@H:25]([CH3:29])[C:26]([OH:28])=[O:27])=[CH:10][C:9]=1[F:30])=[O:7])([CH3:4])[CH3:3].B(C1C=C([Cl:46])C=CC=1O[C@@H](C)C(O)=O)(O)O>>[Cl:46][C:18]1[CH:17]=[CH:16][C:15]([O:24][C@@H:25]([CH3:29])[C:26]([OH:28])=[O:27])=[C:14]([C:11]2[CH:12]=[CH:13][C:8]([C:6]([NH:5][C:2]([CH3:4])([CH3:3])[CH3:1])=[O:7])=[C:9]([F:30])[CH:10]=2)[CH:19]=1

Komponenten

3

Edukt 2

HCID 11539174(2S)-2-[[4'-[[(1,1-dimethylethyl)amino]carbonyl]-3'-fluoro-5-(trifluoromethyl) [1,1'-biphenyl]-2-yl]oxy]-propanoic acidHCID 67277298(2S)-2-(2-borono-4-chlorophenoxy)-propanoic acid

Produkt 1

HCID 11538441(2S)-2-[[5-chloro-4'-[[(1,1-dimethylethyl)amino]carbonyl]-3'-fluoro[1,1'-biphenyl]-2-yl]oxy]-propanoic acid

Versuchsvorschrift

The title compound was prepared using the product of example 33 step a) and the product of example 28 step c) by the method of example 32 step b).

Quellen und Nachweise

ORD-Eintrag
ord-dff6b5a0db1547c19bd0363b932ca948
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07737135B2

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