Reaktionsgleichung
[F:1][C:2]([F:14])([F:13])[C:3]([N:5]1[CH2:12][CH2:11][CH2:10][C@H:6]1[C:7](Cl)=[O:8])=[O:4].[NH2:15][CH2:16][C:17](=[O:19])[CH3:18]>C(Cl)Cl.N1C=CC=CC=1>[O:19]=[C:17]([CH3:18])[CH2:16][NH:15][C:7]([CH:6]1[CH2:10][CH2:11][CH2:12][N:5]1[C:3](=[O:4])[C:2]([F:14])([F:13])[F:1])=[O:8]Komponenten
5
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
A solution of (S)-N-(trifluoroacetyl)prolyl chloride (Aldrich) 1 equiv. in DCM is treated with 1-amino-propan-2-one (1.5 equiv.) in pyridine at rt for 5 hours. After usual work up, it provides 1-trifluoroacetyl-pyrrolidine-2-carboxylic acid (2-oxo-propyl)-amide.
Quellen und Nachweise
- ORD-Eintrag
- ord-67e9145e0ea94a6bbb270e07c82db953
- Quelldatensatz
- uspto-grants-2006_01
- Patentnummer
- US06987104B2
Verknüpfte Notizen
Wird geladen…