3,5-Difluorobenzyl bromide → 1-[(3,5-Difluorophenyl)methyl]-6-(3,5-dimethylbenzoyl)-5-isopropyl-pyrimidine-2,4-dione

HRID 1611329

Reaktionsgleichung

Reaktionsgleichung von HRID 1611329
[CH:1]([C:4]1[C:5](=[O:21])[NH:6][C:7](=[O:20])[NH:8][C:9]=1[C:10](=[O:19])[C:11]1[CH:16]=[C:15]([CH3:17])[CH:14]=[C:13]([CH3:18])[CH:12]=1)([CH3:3])[CH3:2].[F:22][C:23]1[CH:24]=[C:25]([CH:28]=[C:29]([F:31])[CH:30]=1)[CH2:26]Br>>[F:22][C:23]1[CH:24]=[C:25]([CH:28]=[C:29]([F:31])[CH:30]=1)[CH2:26][N:8]1[C:9]([C:10](=[O:19])[C:11]2[CH:12]=[C:13]([CH3:18])[CH:14]=[C:15]([CH3:17])[CH:16]=2)=[C:4]([CH:1]([CH3:3])[CH3:2])[C:5](=[O:21])[NH:6][C:7]1=[O:20]

Komponenten

3

Edukt 2

HCID 5188963,5-Difluorobenzyl bromideHCID 222565826-(3,5-Dimethyl-benzoyl)-5-isopropyl-1H-pyrimidine-2,4-dione

Produkt 1

HCID 52800141-[(3,5-Difluorophenyl)methyl]-6-(3,5-dimethylbenzoyl)-5-isopropyl-pyrimidine-2,4-dioneAusbeute 53,3 %

Versuchsvorschrift

5-Isopropyl-6-(3,5-dimethylbenzoyl)-2,4-pyrimidinedione and 3,5-difluorobenzyl bromide were reacted by the same way with the example 1 to obtain the titled compound (220 mg, yield: 53.3%).

Quellen und Nachweise

ORD-Eintrag
ord-5314071e3e9e4ec9985da4f9ba04657b
Quelldatensatz
uspto-grants-2006_01
Patentnummer
US06987114B1

Verknüpfte Notizen

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