3,6-diethyl-N-(5-methoxy 1,2,3,4-tetrahydronaphthalen-1-yl)pyrazin-2-amine → 5-bromo-3,6-diethyl-N-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)pyrazin-2-amine

HRID 1612180

Reaktionsgleichung

Reaktionsgleichung von HRID 1612180
[Br:1]C1N=C(CC)C(N[C@@H]2C3C(=CC=CC=3)C[C@@H]2O)=NC=1CC.[CH2:23]([C:25]1[C:26]([NH:33][CH:34]2[C:43]3[C:38](=[C:39]([O:44][CH3:45])[CH:40]=[CH:41][CH:42]=3)[CH2:37][CH2:36][CH2:35]2)=[N:27][C:28]([CH2:31][CH3:32])=[CH:29][N:30]=1)[CH3:24]>>[Br:1][C:29]1[N:30]=[C:25]([CH2:23][CH3:24])[C:26]([NH:33][CH:34]2[C:43]3[C:38](=[C:39]([O:44][CH3:45])[CH:40]=[CH:41][CH:42]=3)[CH2:37][CH2:36][CH2:35]2)=[N:27][C:28]=1[CH2:31][CH3:32]

Komponenten

3

Edukt 2

HCID 221474773,6-diethyl-N-(5-methoxy 1,2,3,4-tetrahydronaphthalen-1-yl)pyrazin-2-amineHCID 58583245(1R,2S)-1-[(5-bromo-3,6-diethylpyrazin-2-yl)amino]-2,3-dihydro-1H-inden-2-ol

Produkt 1

HCID 221473935-bromo-3,6-diethyl-N-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)pyrazin-2-amine

Versuchsvorschrift

Following the procedure for the preparation of (1R,2S)-1-[(5-bromo-3,6-diethylpyrazin-2-yl)amino]-2,3-dihydro-1H-inden-2-ol but substituting 3,6-diethyl-N-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)pyrazin-2-amine and making non-critical variations provided the title compound as a oil: 1H NMR (400 MHz, CDCl3) δ) 7.18, 6.97, 6.79, 5.37, 4.53, 2.87-2.76, 2.70-2.64, 2.54, 2.01-1.86, 1.35-1.24; HRMS (FAB) calcd for C19H24BrN3O+H 390.1181, found 390.1186.

Quellen und Nachweise

ORD-Eintrag
ord-c95845ed9a214e2283ea15aa4e40437c
Quelldatensatz
uspto-grants-2006_01
Patentnummer
US06992087B2

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