8-Methoxy-3,4-dihydronaphthalen-1(2H)-one → 6-Methoxy-1-Indanamine

HRID 1612230

Reaktionsgleichung

Reaktionsgleichung von HRID 1612230
O1C2CCCC([NH2:10])C=2C=C1.[CH3:11][O:12][C:13]1[CH:14]=[CH:15][CH:16]=[C:17]2[C:22]=1C(=O)[CH2:20][CH2:19][CH2:18]2>>[CH3:11][O:12][C:13]1[CH:22]=[C:17]2[C:16]([CH2:20][CH2:19][CH:18]2[NH2:10])=[CH:15][CH:14]=1

Komponenten

3

Edukt 2

HCID 112753358-Methoxy-3,4-dihydronaphthalen-1(2H)-oneHCID 185251714,5,6,7-Tetrahydro-1-benzofuran-4-amine

Produkt 1

HCID 99204636-Methoxy-1-Indanamine

Versuchsvorschrift

Following the procedure for the preparation of 4,5,6,7-tetrahydro-1-benzofuran-4-amine but substituting 8-methoxy-3,4-dihydronaphthalen-1(2H)-one and making non-critical variations provided the title compound as a oil: 1H NMR (CDCl3) δ 1.72, 2.54, 2.74, 2.90, 3.83, 4.34, 6.78, 6.91, 7.13; MS (FAB) m/z (rel. intensity) 164 (MH+, 17), 308 (8), 164 (17), 163 (7), 162 (19), 148 (18), 147 (99), 146 (18), 145 (9), 121 (11), 115 (8). HRMS (FAB) calcd for C10H13NO+H 164.1075, found 164.1071.

Quellen und Nachweise

ORD-Eintrag
ord-33366531319843128f6957c7c07936b9
Quelldatensatz
uspto-grants-2006_01
Patentnummer
US06992087B2

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