Triethylamine → Methylsulfamic acid 2-phenoxyethyl ester

HRID 1613821Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1613821
[O:1]([CH2:8][CH2:9][OH:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:11][NH:12][S:13](Cl)(=[O:15])=[O:14].C(N(CC)CC)C>C(#N)C>[O:1]([CH2:8][CH2:9][O:10][S:13](=[O:15])(=[O:14])[NH:12][CH3:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 31236PhenoxyethanolHCID 11789235N-Methylsulfamoyl chloride

Produkt 1

HCID 53869191Methylsulfamic acid 2-phenoxyethyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

This compound was prepared according to the procedure used in Example 112. Thus, a mixture of 14.8 g (0.1 mole) of 2-phenoxyethanol (Matheson, Coleman, and Bell), 15.6 g (0.12 mole) of methylsulfamoyl chloride and 12.3 g (0.12 mole) of triethylamine in 150 ml of acetonitrile gave a viscous oil that solidified upon standing. The solid was recrystallized from benzene-petroleum ether (30°-60° C.) to yield 15.4 g (67%) of shiny, white flakes, mp 66°-68° C.

Aufarbeitung

  1. customThis compound was prepared
  2. customgave a viscous oil that
  3. customThe solid was recrystallized from benzene-petroleum ether (30°-60° C.)
  4. customto yield 15.4 g (67%) of shiny, white flakes, mp 66°-68° C.

Quellen und Nachweise

ORD-Eintrag
ord-ec1d97eca7344bdc914a4f76747d6ff7
Quelldatensatz
uspto-grants-1993_03
Patentnummer
US05194446

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