Quinolinic Acid → 2,3-Piperidinedicarboxylic acid

Beteiligte Stoffe

Reaktionsschritte

Dissolve pyridine-2,3-dicarboxylic acid (20 g, 120 mmol) in 0.5N aqueous sodium hydroxide (900 mL). Add nickel/aluminum powder (45 g) in portions over 3 hours. Stir for 4 days, filter off the catalyst to yield the title compound in clear solution. The resulting free amine is not isolated.

Herkunft & Nachweise