Urea → HCID 19101100, Verbindung

HRID 1614177Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1614177
[CH3:1][C:2]([CH3:14])([C:4](=[O:13])[CH:5](Br)[C:6](=O)[C:7]([CH3:10])([CH3:9])[CH3:8])[CH3:3].[NH2:15][C:16]([NH2:18])=[O:17]>CN(C=O)C>[NH2:18][C:16]1[O:17][C:5]([C:4](=[O:13])[C:2]([CH3:14])([CH3:3])[CH3:1])=[C:6]([C:7]([CH3:10])([CH3:9])[CH3:8])[N:15]=1

Komponenten

4

Edukt 2

HCID 1176UreaHCID 546382Bromo-dipivaloylmethane

Produkt 1

HCID 19101100HCID 19101100, VerbindungAusbeute 42,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

A mixture of 2,2,6,6-tetramethyl-4-bromo-3,5-heptanedione (70 g) and urea (77 g) in DMF (500 mL) is heated at 110°-120° C. overnight. The reaction mixture is cooled and poured into ice water (1500 mL) and the resulting precipitate is collected by filtration and air dried. The solid is rinsed with hexane (1000 mL) and then with isopropyl ether (200 mL) and dried under vacuum overnight to give 1-[2-amino-4-(1,1-dimethylethyl)-5-oxazolyl]-2,2-dimethyl-1-propanone (25.5 g, 42%); mp 248°-250° C.

Aufarbeitung

  1. temperatureis heated at 110°-120° C. overnight
  2. temperatureThe reaction mixture is cooled
  3. filtrationthe resulting precipitate is collected by filtration and air
  4. customdried
  5. washThe solid is rinsed with hexane (1000 mL)
  6. dry with materialwith isopropyl ether (200 mL) and dried under vacuum overnight

Quellen und Nachweise

ORD-Eintrag
ord-03e39079bec64e41938e576d27c33df8
Quelldatensatz
uspto-grants-1993_03
Patentnummer
US05196431

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