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Hydrochloric Acid → HCID 14674164, Verbindung

HRID 1614210
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 1614210
Br[CH2:2][C:3]([C:5]1[CH:14]=[CH:13][C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=1)=[O:4].[ClH:15].[N+:16]([C:19]1[CH:20]=[C:21]([CH:29]=[CH:30][CH:31]=1)[O:22][CH:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1)([O-:18])=[O:17].C(N(CC)CC)C.Cl>C(O)C>[ClH:15].[N+:16]([C:19]1[CH:20]=[C:21]([CH:29]=[CH:30][CH:31]=1)[O:22][CH:23]1[CH2:24][CH2:25][N:26]([CH2:2][C:3]([C:5]2[CH:14]=[CH:13][C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[CH:6]=2)=[O:4])[CH2:27][CH2:28]1)([O-:18])=[O:17]
KomponentenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 8471TriethylamineHCID 691792-Bromo-2'-acetonaphthoneHCID 224033414-(3-Nitrophenoxy)piperidine hydrochloride

Produkt 1

HCID 14674164HCID 14674164, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702
Ethanol
Lösungsmittel

Versuchsvorschrift

0.63 g of 2-bromo-2'-acetonaphthone, 0.65 g of 4-(m-nitrophenoxy)piperidine hydrochloride, and 1 g of triethylamine were added to 100 ml of ethanol. The mixture was refluxed for 30 min. The solvent was distilled off, and dichloromethane was added to the residue. The mixture was washed with water and dried. The dichloromethane was distilled off, and the residue was purified by column chromatography (silica gel) to prepare an oleaginous intended compound. The compound was converted into a hydrochloride by an ordinary method and then recrystallized to prepare 0.15 g of an intended hydrochloride.

Aufarbeitung

  1. temperatureThe mixture was refluxed for 30 min
  2. distillationThe solvent was distilled off
  3. additiondichloromethane was added to the residue
  4. washThe mixture was washed with water
  5. customdried
  6. distillationThe dichloromethane was distilled off
  7. customthe residue was purified by column chromatography (silica gel)
  8. customto prepare an oleaginous intended compound
  9. customrecrystallized
  10. customto prepare 0.15 g of an intended hydrochloride

Quellen und Nachweise

ORD-Eintrag
ord-0036256189be44d4a9a75fe69f54fd79
Quelldatensatz
uspto-grants-1993_03
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US05196439

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