Benzenepropanal → 3-(Pyrimidin-5-yloxy)-4,5-dihydroisoxazole

HRID 1614989Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1614989
[N:1]1[CH:6]=C[CH:4]=[C:3]([O:7][C:8]2[CH2:12][CH2:11][O:10][N:9]=2)[CH:2]=1.OC1C=[N:16]C=NC=1.C(=O)CCC1C=CC=CC=1>>[N:1]1[CH:2]=[C:3]([O:7][C:8]2[CH2:12][CH2:11][O:10][N:9]=2)[CH:4]=[N:16][CH:6]=1

Komponenten

4

Edukt 3

HCID 7707BenzenepropanalHCID 565855Pyrimidin-5-olHCID 668185323-(Pyridin-3-yloxy)-4,5-dihydroisoxazole

Produkt 1

HCID 866505643-(Pyrimidin-5-yloxy)-4,5-dihydroisoxazole

Versuchsvorschrift

3-(Pyrimidin-5-yloxy)-4,5-dihydroisoxazole III-54 was prepared in 3 steps from compound III-9 starting with the synthesis of 3-(pyridin-3-yloxy)-4,5-dihydroisoxazole III-53 from compound III-9 and 5-hydroxypyrimidine using Method 5. Compound III-53 is then deprotected using analogous conditions to Example 11 and then converted to desired product III-54 using the analogous procedure as Example 13 except that hydrocinnamaldehyde was used in the place of benzoyl chloride. [M+H]+=367.6 m/z. Activity: B

Quellen und Nachweise

ORD-Eintrag
ord-168bf05c78e541079bb32ff581c9b139
Quelldatensatz
uspto-grants-2014_07
Patentnummer
US08765735B2

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