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HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 1615162Erstellt: 26. Oktober 2026

(S)-1-(3,4-Difluorophenyl)ethanamine → 9-{2-[(S)-1-(3,4-Difluoro-phenyl)-ethylamino]-ethyl}-3,3-dimethyl-1,5-dioxa-spiro[5.5]undecan-9-ol

https://huagongshe.com/reaction/1615162

Reaktionsgleichung

Beteiligte Stoffe

RolleNameHCIDEinwaage
Edukt(S)-1-(3,4-Difluorophenyl)ethanamineHCID 7016601—
Edukt(9-Hydroxy-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-9-yl)-acetaldehydeHCID 86668369—
Produkt9-{2-[(S)-1-(3,4-Difluoro-phenyl)-ethylamino]-ethyl}-3,3-dimethyl-1,5-dioxa-spiro[5.5]undecan-9-olHCID 6799634654%

Reaktionsschritte

The title compound is prepared from (9-hydroxy-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-9-yl)-acetaldehyde and (S)-1-(3,4-difluoro-phenyl)-ethylamine following a procedure analogous to that described in Step 3 of Intermediate 2. Yield: 54% of theory; LC (method 5): tR=1.00 min; Mass spectrum (ESI+): m/z=384 [M+H]+.

Herkunft & Nachweise

DOI10.6084/m9.figshare.5104873.v1
PatentnummerUS08765744B2
Quelldatensatzuspto-grants-2014_07
ORD IDord-92ea6f01d08c4452b87939a77e7e051e
Quellennotizuspto-grants-2014_07