Hydrochloric Acid → (R)-methyl 2-(3-(3,5-difluorophenyl)-5-oxo-8,11-dioxa-1,4-diazaspiro[5.6]dodecan-4-yl)acetate hydrochloride

HRID 1615765Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1615765
[F:1][C:2]1[CH:3]=[C:4]([C@H:9]2[N:14]([CH2:15][C:16]([O:18][CH3:19])=[O:17])[C:13](=[O:20])[C:12]3([CH2:26][O:25][CH2:24][CH2:23][O:22][CH2:21]3)[N:11](C(OC(C)(C)C)=O)[CH2:10]2)[CH:5]=[C:6]([F:8])[CH:7]=1.[ClH:34]>>[ClH:34].[F:8][C:6]1[CH:5]=[C:4]([C@H:9]2[N:14]([CH2:15][C:16]([O:18][CH3:19])=[O:17])[C:13](=[O:20])[C:12]3([CH2:21][O:22][CH2:23][CH2:24][O:25][CH2:26]3)[NH:11][CH2:10]2)[CH:3]=[C:2]([F:1])[CH:7]=1

Komponenten

3

Edukt 2

HCID 313Hydrochloric AcidHCID 68154574tert-butyl (R)-3-(3,5-difluoro-phenyl)-4-methoxycarbonylmethyl-5-oxo-8,11-dioxa-1,4-diaza-spiro[5.6]dodecane-1-carboxylate

Produkt 1

HCID 68154674(R)-methyl 2-(3-(3,5-difluorophenyl)-5-oxo-8,11-dioxa-1,4-diazaspiro[5.6]dodecan-4-yl)acetate hydrochloride

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

0.13 g (0.28 mmol) tert-butyl (R)-3-(3,5-difluoro-phenyl)-4-methoxycarbonylmethyl-5-oxo-8,11-dioxa-1,4-diaza-spiro[5.6]dodecane-1-carboxylate were combined with 20 ml of a 1M methanolic hydrochloric acid solution and stirred for 2 h at 50° C. The reaction mixture was concentrated by rotary evaporation and further reacted without any further purification.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated by rotary evaporation
  2. customfurther reacted without any further purification

Quellen und Nachweise

ORD-Eintrag
ord-f635bd57fb15454dbdaabded8c7ea9e0
Quelldatensatz
uspto-grants-2014_07
Patentnummer
US08765763B2

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