Methyl iodide → (R)-methyl 2-(3-(3,5-difluorophenyl)-1-methyl-5-oxo-8,11-dioxa-1,4-diazaspiro[5.6]dodecan-4-yl)acetate

HRID 1615766Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1615766
Cl.[F:2][C:3]1[CH:4]=[C:5]([C@H:10]2[N:15]([CH2:16][C:17]([O:19][CH3:20])=[O:18])[C:14](=[O:21])[C:13]3([CH2:27][O:26][CH2:25][CH2:24][O:23][CH2:22]3)[NH:12][CH2:11]2)[CH:6]=[C:7]([F:9])[CH:8]=1.[C:28](=O)([O-])[O-].[K+].[K+].CI>C(#N)C>[F:9][C:7]1[CH:6]=[C:5]([C@H:10]2[N:15]([CH2:16][C:17]([O:19][CH3:20])=[O:18])[C:14](=[O:21])[C:13]3([CH2:22][O:23][CH2:24][CH2:25][O:26][CH2:27]3)[N:12]([CH3:28])[CH2:11]2)[CH:4]=[C:3]([F:2])[CH:8]=1

Komponenten

5

Edukt 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 68154674(R)-methyl 2-(3-(3,5-difluorophenyl)-5-oxo-8,11-dioxa-1,4-diazaspiro[5.6]dodecan-4-yl)acetate hydrochloride

Produkt 1

HCID 68154310(R)-methyl 2-(3-(3,5-difluorophenyl)-1-methyl-5-oxo-8,11-dioxa-1,4-diazaspiro[5.6]dodecan-4-yl)acetate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

0.10 g (0.25 mmol) (R)-methyl 2-(3-(3,5-difluorophenyl)-5-oxo-8,11-dioxa-1,4-diazaspiro[5.6]dodecan-4-yl)acetate hydrochloride in 20 ml acetonitrile were combined with 83 mg (0.60 mmol) potassium carbonate and with 0.04 ml (0.60 mmol) methyl iodide. The reaction mixture was stirred for 5 days at RT. Then the reaction was evaporated down and reacted without any further purification.

Aufarbeitung

  1. customThen the reaction was evaporated down
  2. customreacted without any further purification

Quellen und Nachweise

ORD-Eintrag
ord-92c5193428574d368692de44c42a9bd2
Quelldatensatz
uspto-grants-2014_07
Patentnummer
US08765763B2

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