Piperidine → Methyl 1-oxo-2-(2-piperidin-1-ylethyl)-1,2-dihydroisoquinoline-7-carboxylate

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Reaktionsgleichung

Br[CH2:2][CH2:3][N:4]1[CH:13]=[CH:12][C:11]2[C:6](=[CH:7][C:8]([C:14]([O:16][CH3:17])=[O:15])=[CH:9][CH:10]=2)[C:5]1=[O:18].[NH:19]1[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1>>[O:18]=[C:5]1[C:6]2[C:11](=[CH:10][CH:9]=[C:8]([C:14]([O:16][CH3:17])=[O:15])[CH:7]=2)[CH:12]=[CH:13][N:4]1[CH2:3][CH2:2][N:19]1[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1

Komponenten

Edukt 2

HCID 8082Piperidine

HCID 67281903Methyl 2-(2-bromoethyl)-1-oxo-1,2-dihydroisoquinoline-7-carboxylate

Produkt 1

HCID 67282768Methyl 1-oxo-2-(2-piperidin-1-ylethyl)-1,2-dihydroisoquinoline-7-carboxylate

Versuchsvorschrift

The title compound was prepared from methyl 2-(2-bromoethyl)-1-oxo-1,2-dihydroisoquinoline-7-carboxylate (96 mg, 0.31 mmol) and piperidine (0.31 mL, 3.1 mmol) following the procedure outlined in Example 44, step 2 (80 mg, 82%). LC-MS: (FA) ES+ 315.

Quellen und Nachweise

ORD-Eintrag: ord-56d14f495fff4f3d82baa13fd9c4dc37
Quelldatensatz: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US08765773B2

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