2-Bromopropane → HCID 67323888, Verbindung

To a mixture of 3-bromo-2-fluoro-phenol (2 g, 10 mmol) and cesium carbonate (10 g, 40 mmol) in acetonitrile (20 mL) was added 2-bromopropane (4 mL, 50 mmol). The reaction mixture was stirred at 80° C. for 4 h. The mixture was filtered through a plug of Celite and eluted with ethyl acetate. The resulting solution was evaporated. The residue was purified by flash chromatography on silica gel and eluting with hexanes:EtOAc (1:1) to afford the title product (1.7 g).

1. filtrationThe mixture was filtered through a plug of Celite
2. washeluted with ethyl acetate
3. customThe resulting solution was evaporated
4. customThe residue was purified by flash chromatography on silica gel
5. washeluting with hexanes:EtOAc (1:1)

ORD-Eintrag

ord-3b4c517765b944678391a94b6620727b

Quelldatensatz

uspto-grants-2014_07

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08765779B2