Potassium Cyanide → HCID 178433372, Verbindung

HRID 1617205Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1617205
[C-:1]#[N:2].[K+].Cl.[NH2:5][C:6]1[N:11]=[C:10]([OH:12])[C:9]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([CH2:20]Cl)=[CH:16][CH:15]=2)=[C:8]([CH3:22])[N:7]=1>CN(C=O)C.CS(C)=O>[NH2:5][C:6]1[N:11]=[C:10]([OH:12])[C:9]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([CH2:20][C:1]#[N:2])=[CH:16][CH:15]=2)=[C:8]([CH3:22])[N:7]=1

Komponenten

5

Edukt 2

HCID 9032Potassium CyanideHCID 178433371HCID 178433371, Verbindung

Produkt 1

HCID 178433372HCID 178433372, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 679Dimethyl SulfoxideLösungsmittelHCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

Potassium cyanide (2 g) was added to a solution of the product from step (ii) in DMF (20 ml) and DMSO (10 ml) and the mixture stirred at rt for 18 h. The mixture was flushed with nitrogen for 20 min, then diluted with brine (80 ml), stirred for 10 min and the precipitate filtered, washed with water then ether and dried to afford the subtitle compound, 2.46 g.

Aufarbeitung

  1. customThe mixture was flushed with nitrogen for 20 min
  2. additiondiluted with brine (80 ml)
  3. stirringstirred for 10 min
  4. filtrationthe precipitate filtered
  5. washwashed with water
  6. dry with materialether and dried

Quellen und Nachweise

ORD-Eintrag
ord-2ea4a16d71b64e6e97ad915f5099e11a
Quelldatensatz
uspto-grants-2014_07
Patentnummer
US08765939B2

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