Imidazole → HCID 86633411, Verbindung

HRID 1617214Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1617214
[NH2:1][CH2:2][C@@H:3]([OH:6])[CH2:4][CH3:5].[C:7]([Si:11](Cl)([CH3:13])[CH3:12])([CH3:10])([CH3:9])[CH3:8].N1C=CN=C1>CN(C=O)C>[Si:11]([O:6][C@@H:3]([CH2:4][CH3:5])[CH2:2][NH2:1])([C:7]([CH3:10])([CH3:9])[CH3:8])([CH3:13])[CH3:12]

Komponenten

5

Edukt 3

HCID 795ImidazoleHCID 28928tert-Butyldimethylsilyl chlorideHCID 6995554(2S)-1-Amino-2-butanol

Produkt 1

HCID 86633411HCID 86633411, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

To the product from step (ii) (310 mg) in DMF (10 mL), tert-butylchlorodimethylsilane (734 mg) was added followed by imidazole (474 mg) and stirred at rt for 24 h. The mixture was washed with water and extracted with EtOAc, dried and the solvent removed to give the subtitle compound as a yellow oil, 610 mg.

Aufarbeitung

  1. washThe mixture was washed with water
  2. extractionextracted with EtOAc
  3. customdried
  4. customthe solvent removed

Quellen und Nachweise

ORD-Eintrag
ord-5d32d2228e174c0aad85ed422d86ecff
Quelldatensatz
uspto-grants-2014_07
Patentnummer
US08765939B2

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