Methanol → Methyl 2-(3-((2-amino-4-methyl-6-(pentylamino)pyrimidin-5-yl)methyl)-4-methoxyphenyl)acetate

HRID 1617219Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1617219
[NH2:1][C:2]1[N:7]=[C:6]([CH3:8])[C:5]([CH2:9][C:10]2[CH:11]=[C:12]([CH2:18][C:19]([OH:21])=[O:20])[CH:13]=[CH:14][C:15]=2[O:16][CH3:17])=[C:4]([NH:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])[N:3]=1.[CH3:28]O>Cl.O1CCOCC1>[NH2:1][C:2]1[N:7]=[C:6]([CH3:8])[C:5]([CH2:9][C:10]2[CH:11]=[C:12]([CH2:18][C:19]([O:21][CH3:28])=[O:20])[CH:13]=[CH:14][C:15]=2[O:16][CH3:17])=[C:4]([NH:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])[N:3]=1

Komponenten

5

Edukt 2

HCID 887MethanolHCID 684129432-(3-((2-Amino-4-methyl-6-(pentylamino)pyrimidin-5-yl)methyl)-4-methoxyphenyl)acetic acid

Produkt 1

HCID 42613398Methyl 2-(3-((2-amino-4-methyl-6-(pentylamino)pyrimidin-5-yl)methyl)-4-methoxyphenyl)acetate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 313Hydrochloric AcidLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

A solution of the product from step (iv) (135 mg) in MeOH (5 ml) and 4M HCl in dioxane (0.5 ml) was stirred at rt for 18 h. The solvent was evaporated and the residue purified by RPHPLC to give the title compound as a solid, 31 mg.

Aufarbeitung

  1. customThe solvent was evaporated
  2. customthe residue purified by RPHPLC

Quellen und Nachweise

ORD-Eintrag
ord-dd7c34c4bb2d442fb9259ff242617b42
Quelldatensatz
uspto-grants-2014_07
Patentnummer
US08765939B2

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