Ethanol → 2-(4-(2-Amino-4-(butylamino)-6-methylpyrimidin-5-ylthio)phenyl)acetic acid

HRID 1617258Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1617258
[NH2:1][C:2]1[N:7]=[C:6]([NH:8][CH2:9][CH2:10][CH2:11][CH3:12])[C:5]([S:13][C:14]2[CH:19]=[CH:18][C:17](CC#N)=[CH:16][CH:15]=2)=[C:4]([CH3:23])[N:3]=1.[OH-:24].[K+].[CH3:26][CH2:27][OH:28]>>[NH2:1][C:2]1[N:7]=[C:6]([NH:8][CH2:9][CH2:10][CH2:11][CH3:12])[C:5]([S:13][C:14]2[CH:19]=[CH:18][C:17]([CH2:26][C:27]([OH:24])=[O:28])=[CH:16][CH:15]=2)=[C:4]([CH3:23])[N:3]=1

Komponenten

4

Edukt 3

HCID 702EthanolHCID 14797Potassium HydroxideHCID 684153862-(4-(2-Amino-4-(butylamino)-6-methylpyrimidin-5-ylthio)phenyl)acetonitrile

Produkt 1

HCID 684157402-(4-(2-Amino-4-(butylamino)-6-methylpyrimidin-5-ylthio)phenyl)acetic acid

Versuchsvorschrift

A mixture of the product from step (v) (610 mg) and aq. 5M KOH (2 ml) in EtOH (8 ml) was heated under reflux for 18 h. The mixture was purified by RPHPLC to give the subtitle compound as a solid, 392 mg.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureunder reflux for 18 h
  3. customThe mixture was purified by RPHPLC

Quellen und Nachweise

ORD-Eintrag
ord-3a047b80770649eca06d0cd12a12f313
Quelldatensatz
uspto-grants-2014_07
Patentnummer
US08765939B2

Notizen zur Reaktion

Wird geladen…