4-(Dimethylamino)butan-1-ol → 4-(Dimethylamino)butyl 2-(4-((2-amino-4-(butylamino)-6-methylpyrimidin-5-yl)methyl)-3-hydroxyphenyl)acetate

HRID 1617262

Reaktionsgleichung

Reaktionsgleichung von HRID 1617262
[NH2:1][C:2]1[N:7]=[C:6]([NH:8][CH2:9][CH2:10][CH2:11][CH3:12])[C:5]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([CH2:20][C:21]([OH:23])=[O:22])=[CH:16][C:15]=2[OH:24])=[C:4]([CH3:25])[N:3]=1.[CH3:26][N:27]([CH3:33])[CH2:28][CH2:29][CH2:30][CH2:31]O>>[NH2:1][C:2]1[N:7]=[C:6]([NH:8][CH2:9][CH2:10][CH2:11][CH3:12])[C:5]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([CH2:20][C:21]([O:23][CH2:31][CH2:30][CH2:29][CH2:28][N:27]([CH3:33])[CH3:26])=[O:22])=[CH:16][C:15]=2[OH:24])=[C:4]([CH3:25])[N:3]=1

Komponenten

3

Edukt 2

HCID 833504-(Dimethylamino)butan-1-olHCID 684141362-(4-((2-Amino-4-(butylamino)-6-methylpyrimidin-5-yl)methyl)-3-hydroxyphenyl)acetic acid

Produkt 1

HCID 578248444-(Dimethylamino)butyl 2-(4-((2-amino-4-(butylamino)-6-methylpyrimidin-5-yl)methyl)-3-hydroxyphenyl)acetate

Versuchsvorschrift

The title compound was prepared using product of example 79 step (i) (80 mg) and 4-(dimethylamino)butan-1-ol using the general coupling method of example 74 step (iii). The product was purified by RPHPLC to give the product, 25 mg.

Aufarbeitung

  1. customThe product was purified by RPHPLC
  2. customto give the product, 25 mg

Quellen und Nachweise

ORD-Eintrag
ord-8cfc86100e3348eb866ce21acd8e6255
Quelldatensatz
uspto-grants-2014_07
Patentnummer
US08765939B2

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