2-Fluoro-4-iodo-5-methylpyridine → 1-(2-Fluoro-5-methyl-pyridin-4-yl)-3,3-diphenyl-propan-1-one
Reaktionsgleichung
CON(C)[C:4](=[O:19])[CH2:5][CH:6]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[F:21][C:22]1[CH:27]=[C:26](I)[C:25]([CH3:29])=[CH:24][N:23]=1>>[F:21][C:22]1[CH:27]=[C:26]([C:4](=[O:19])[CH2:5][CH:6]([C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)[C:25]([CH3:29])=[CH:24][N:23]=1Komponenten
3
Versuchsvorschrift
In analogy to example 55, step 2, the title compound was prepared from N-methoxy-N-methyl-3,3-diphenyl-propionamide and 2-fluoro-4-iodo-5-picoline (CAS RN: [153034-94-7]) as a yellow liquid, MS (ESI+): m/z=320.1 ([M+H]+).
Quellen und Nachweise
- ORD-Eintrag
- ord-eaac8e3a5c014ed6aa35ea2ad3f31e3f
- Quelldatensatz
- uspto-grants-2014_07