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HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 1617513Erstellt: 24. Oktober 2026

2-Fluoro-4-(methoxycarbonyl)benzeneboronic acid → 2-Fluoro-4'-[3-(2-methyl-pyridin-4-yl)-3-oxo-1-o-tolyl-propyl]-biphenyl-4-carboxylic acid methyl ester

https://huagongshe.com/de/reaction/1617513

Reaktionsgleichung

Beteiligte Stoffe

RolleNameHCIDEinwaage
Edukt2-Fluoro-4-(methoxycarbonyl)benzeneboronic acidHCID 24824345—
Edukt3-(4-Bromo-phenyl)-1-(2-methyl-pyridin-4-yl)-3-o-tolyl-propan-1-oneHCID 66668180—
Produkt2-Fluoro-4'-[3-(2-methyl-pyridin-4-yl)-3-oxo-1-o-tolyl-propyl]-biphenyl-4-carboxylic acid methyl esterHCID 66666683—

Reaktionsschritte

In analogy to example 74, step 6, from 3-(4-bromo-phenyl)-1-(2-methyl-pyridin-4-yl)-3-o-tolyl-propan-1-one (example 74, step 5) and 2-fluoro-4-(methoxycarbonyl)phenylboronic acid was prepared the title compound as a light brown oil, MS (ESI+): m/z=468.1961 ([M+H]+).

Herkunft & Nachweise

DOI10.6084/m9.figshare.5104873.v1
PatentnummerUS08765730B2
Quelldatensatzuspto-grants-2014_07
ORD IDord-505d367c4e9a47a4bbe0e38af98db6ba
Quellennotizuspto-grants-2014_07