2-Fluoro-4-iodo-6-methylpyridine → 3-(4-Bromo-phenyl)-1-(2-fluoro-6-methyl-pyridin-4-yl)-3-o-tolyl-propan-1-one
Reaktionsgleichung
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[CH3:22])[CH2:9][C:10](N(OC)C)=[O:11])=[CH:4][CH:3]=1.[F:23][C:24]1[CH:29]=[C:28](I)[CH:27]=[C:26]([CH3:31])[N:25]=1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[CH3:22])[CH2:9][C:10]([C:28]2[CH:27]=[C:26]([CH3:31])[N:25]=[C:24]([F:23])[CH:29]=2)=[O:11])=[CH:6][CH:7]=1Komponenten
3
Versuchsvorschrift
In analogy to example 74, step 5, from 3-(4-bromo-phenyl)-N-methoxy-N-methyl-3-o-tolyl-propionamide (example 74, step 4) and 2-fluoro-4-iodo-6-picoline (CAS RN: [884494-45-5]) was prepared the title compound as a colorless oil, MS (EI): m/z=411 ([M]+, 1Br).
Quellen und Nachweise
- ORD-Eintrag
- ord-d844bad79bce40e6866f827298cf3c9f
- Quelldatensatz
- uspto-grants-2014_07
- DOI