HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Pyridine → HCID 66668771, Verbindung
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Pyridine | HCID 1049 | — |
| Edukt | (4-Chloro-3-(ethoxycarbonyl)phenyl)boronic acid | HCID 44119820 | — |
| Edukt | HCID 66669183 | HCID 66669183 | — |
| Katalysator | Cupric acetate | HCID 8895 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Produkt | HCID 66668771 | HCID 66668771 | — |
Reaktionsschritte
In analogy to example 222, step 1, 5-[3-(4-chloro-2-methyl-phenyl)-3-(3-fluoro-4-hydroxy-phenyl)-propionyl]-1-methyl-1H-pyridin-2-one (example 324, step 1) was reacted with 4-chloro-3-ethoxycarbonylphenylboronic acid in dichloromethane in the presence of copper(II) acetate, pyridine and air to give the title compound as a colourless solid, MS (ESI+): m/z=582.2 [M+H]+.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08765730B2 |
| Quelldatensatz | uspto-grants-2014_07 |
| ORD ID | ord-b92d78002d3e449785b039df925833a7 |
| Quellennotiz | uspto-grants-2014_07 |