3-Methoxybenzenethiol → {[4-Hydroxy-1-(3-methoxy-phenylsulfanyl)-isoquinoline-3-carbonyl]-amino}-acetic acid

HRID 1618293

Reaktionsgleichung

Reaktionsgleichung von HRID 1618293
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([OH:12])=[C:4]([C:13]([NH:15][CH2:16][C:17]([OH:19])=[O:18])=[O:14])[N:3]=1.[CH3:20][O:21][C:22]1[CH:23]=[C:24]([SH:28])[CH:25]=[CH:26][CH:27]=1>>[OH:12][C:5]1[C:6]2[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=2)[C:2]([S:28][C:24]2[CH:25]=[CH:26][CH:27]=[C:22]([O:21][CH3:20])[CH:23]=2)=[N:3][C:4]=1[C:13]([NH:15][CH2:16][C:17]([OH:19])=[O:18])=[O:14]

Komponenten

3

Edukt 2

HCID 849893-MethoxybenzenethiolHCID 6914666FG-2216

Produkt 1

HCID 66712952{[4-Hydroxy-1-(3-methoxy-phenylsulfanyl)-isoquinoline-3-carbonyl]-amino}-acetic acid

Versuchsvorschrift

The title compound was prepared from [(1-chloro-4-hydroxy-isoquinoline-3-carbonyl)-amino]-acetic acid (U.S. Pat. No. 6,093,730) and 3-methoxybenzenethiol under conditions analogous to Example D-110. The final product was precipitated from a solution of ethyl acetate using hexanes; MS (−) m/z 385.12 (M−1)

Aufarbeitung

  1. customThe final product was precipitated from a solution of ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-98a36eb45bf148738c98dfc0a503e75e
Quelldatensatz
uspto-grants-2014_07
Patentnummer
US08765956B2

Verknüpfte Notizen

Wird geladen…