Hydrogen Peroxide → 2-Amino-4-bromo-6-fluorobenzoic acid

HRID 1619329Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1619329
[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6](=[O:12])C(=O)[NH:8]2)=[C:4]([F:13])[CH:3]=1.[OH:14]O>[OH-].[Na+]>[NH2:8][C:9]1[CH:10]=[C:2]([Br:1])[CH:3]=[C:4]([F:13])[C:5]=1[C:6]([OH:12])=[O:14]

Komponenten

4

Edukt 2

HCID 784Hydrogen PeroxideHCID 672585381312454-85-5

Produkt 1

HCID 672576072-Amino-4-bromo-6-fluorobenzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 14798Sodium HydroxideLösungsmittel

Versuchsvorschrift

To a solution of 6-bromo-4-fluoroindoline-2,3-dione (7.4 g, 31.8 mmol) in 1 M NaOH (100 mL) was added 38% H2O2 (13 mL) dropwise. The resulting solution was stirred at rt for 2 h. The mixture was filtered and the filtrate was acidified using hydrochloric acid (2 N) till pH became around 2. The precipitate was formed and filtered, washed with water, dried under vacuum to give 2.8 g of the desired product. MS (ESI): 232, 234 (MH−).

Aufarbeitung

  1. filtrationThe mixture was filtered
  2. customThe precipitate was formed
  3. filtrationfiltered
  4. washwashed with water
  5. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-f322590bfeb841a2a8db703f119164dd
Quelldatensatz
uspto-grants-2014_07
Patentnummer
US08772301B2

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